Arterial Hypertension in Rats

1. When rats developed cardiac hypertrophy or elevation of blood pressure as a result of one of several methods designed to bring about arterial hypertension, renal vascular disease occurred frequently. 2. When injury to one kidney was followed by cardiac hypertrophy or elevation of blood pressure, vascular lesions were found with considerable regularity in the opposite one, as well as in the one injured. 3. Renal lesions rarely occurred in the absence of cardiac hypertrophy or elevated blood pressure. 4. Renal vascular lesions in rats are occasioned, therefore, by injury to one kidney and are usually associated with, and dependent on, the presence of arterial hypertension.